Well, its hands down for me. Targus is a much better backpack to me than the SwissGear. I have had this Targus for 7 years now, while Ive only had the SwissGear for only about 4 years now. Notice in the pictures, the shape of the two. The Targus is still in very good shape,while the SwissGear is torn where you see the RED circles.
The Targus backpack:
The SwissGear backpack: